Drug overdose deaths among men have risen sharply over the last decade, with Black and American Indian/Alaskan Native (AI/AN) men experiencing the steepest increases. By 2022, overdose death rates for Black men and AI/AN men far surpassed those for white men. Once perceived as a crisis primarily affecting white men, the opioid epidemic has increasingly devastated other racial groups, driven by the emergence of fentanyl. Older Black men are at particularly high risk, with overdose rates peaking later in life compared to white men.
Geographically, Midwestern states like Wisconsin and Minnesota, as well as urban areas like Washington D.C., have the largest racial disparities.
The shift from prescription opioids to synthetic drugs like fentanyl has disproportionately impacted Black communities. Economic instability, housing challenges, COVID-19, and limited access to effective treatments like medication-assisted treatment, exacerbated overdose risks.
Since 2001, male deaths from drug overdose have increased almost sixfold, and now account for a third of male fatal injuries, up from around one-tenth. (For more details on overall trends in accidental deaths, see our earlier brief “Unnatural Male Deaths: Fatal Injuries and the Rise of Drug Overdoses”).
Between 2008 and 2016, Black men had substantially lower overdose rates compared to white and AI/AN men. By 2018, the Black male drug death rate (28 per 100,000) had nearly converged with white and AI/AN men (both 30 per 100,000). In the years that followed, rates among Black and AI/AN men rose sharply, far exceeding other racial groups.
By 2022, AI/AN men had the highest age-adjusted drug death rate at 81 per 100,000, followed closely by Black men at 69 per 100,000 – rates that are 80% and 53% higher, respectively, than white men. While the national age-adjusted drug overdose death rate slightly decreased in 2023 (from 32.6 per 100,000 in 2022 to 31.3), the rate among the Black population continued to rise (47.5 to 48.9).
Figure 1
The sharp rise in overdose deaths among Black men in the late 2010s was driven primarily by the increasing availability and lethality of synthetic opioids like fentanyl. The prior wave of the opioid epidemic was largely fueled by prescription painkillers, which peaked in 2011, accounting for 38% of all overdose deaths nationwide, and predominantly impacted white populations. The subsequent reduction in prescription opioid availability, while addressing misuse, coincided with the rise of more potent, cheaper, and unregulated alternatives—such as fentanyl. From 2011-2022, the share of Black overdose deaths involving prescription opioids decreased from 24% to 9% (a 62% decline), compared to a decrease from 39% to 17% for white (a 56% decline). During that same time period, the share of overdose deaths involving synthetic opioids rose dramatically, increasing from 4% to 73% among Black, and from 7% to 67% among white.
The use of synthetic opioids, particularly fentanyl, began to surge in Black communities around 2014–2015, with mortality rates rising sharply by the late 2010s. By 2022, fentanyl was the leading driver of opioid-related deaths among Black men. Deaths involving cocaine and psychostimulants have also risen dramatically, with cocaine-related fatalities seeing a particularly sharp increase.
Figure 2
The high potency of fentanyl makes it especially dangerous, often leading to death even in small doses. Compounding the problem, Black men are at high risk for polysubstance use, where fentanyl is often mixed with other drugs, such as cocaine or stimulants, sometimes without the user’s knowledge.
Among Black men, those aged 55-64 experience the highest overdose death rates, followed by those aged 45-54. Black men aged 45-64 were 2.3 times as likely to die compared to similarly-aged white men. As shown in Figure 3, the risk of overdose mortality among white men starts to decline by age 45, while Black men’s risk continues to rise until age 65. Black men aged 65 and over were 5.6 times as likely to die by drug overdose compared to their white peers.
Figure 3
A recent New York Times article highlights how these dynamics have devastated a whole generation of Black men, destabilizing families and communities. It discusses the significant barriers older Black men face when accessing addiction treatment and gold-standard medications for opioid use disorder. Medicare’s reduced coverage for addiction services, combined with harm reduction programs that often target younger populations, leaves older men underserved despite their unique challenges and higher risks.
The gap between Black and white men in the risk of death from drug overdose varies considerably across states. Wisconsin, Minnesota, and Nebraska exhibit the largest racial disparities in drug overdose deaths among men, with Black men more than four times as likely to die of an overdose compared to white men, as the map below shows.
Figure 4
In Washington D.C., Black men are over nine times more likely to die from a drug overdose, a disparity similar to that of other urban areas in the region. Mississippi, South Carolina, Georgia, and Florida are the only states where Black men are less likely to die from drug overdoses compared to their white counterparts.
Drug abuse and overdose deaths are influenced by a range of factors, including economic instability, housing challenges, interpersonal trauma, and access to healthcare. An important question for health practitioners and policymakers is why the death rates for Black men have risen so rapidly in recent years. Possible explanations include:
The levels of male deaths from drug overdose have risen to crisis levels. As we showed in our earlier brief, the increase in deaths since 2001 equates to the loss of an additional 400,000 lives, about the same as the number of U.S. men who died in World War II. But the racial pattern of drug deaths has also shifted, with Black and AI/AN men now at the highest risk.
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